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Paola Dessanti Selected Research

Leukemia

1/2020Tranylcypromine-Based LSD1 Inhibitors: Structure-Activity Relationships, Antiproliferative Effects in Leukemia, and Gene Target Modulation.
1/2017Novel potent inhibitors of the histone demethylase KDM1A (LSD1), orally active in a murine promyelocitic leukemia model.
2/2016Discovery of a Novel Inhibitor of Histone Lysine-Specific Demethylase 1A (KDM1A/LSD1) as Orally Active Antitumor Agent.
4/2015Pure enantiomers of benzoylamino-tranylcypromine: LSD1 inhibition, gene modulation in human leukemia cells and effects on clonogenic potential of murine promyelocytic blasts.

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Paola Dessanti Research Topics

Disease

7Neoplasms (Cancer)
07/2022 - 10/2014
4Leukemia
01/2020 - 04/2015
2Virus Diseases (Viral Diseases)
07/2022 - 10/2014
1Mental Disorders (Mental Disorder)
07/2022
1Multiple Sclerosis
07/2022
1Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental)
07/2022
1Encephalomyelitis (Myeloencephalitis)
07/2022
1Neurodegenerative Diseases (Neurodegenerative Disease)
07/2022
1Demyelinating Diseases (Demyelinating Disease)
07/2022
1Neuroinflammatory Diseases
07/2022
1Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
01/2017
1Neuroblastoma
01/2017
1Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
01/2017

Drug/Important Bio-Agent (IBA)

3Tranylcypromine (Parnate)FDA LinkGeneric
12/2021 - 04/2015
2Proteins (Proteins, Gene)FDA Link
07/2022 - 12/2021
2AminesIBA
12/2021 - 01/2017
2Oxidoreductases (Dehydrogenase)IBA
12/2021 - 01/2017
2Lysine (L-Lysine)FDA Link
01/2020 - 03/2015
2Histone DemethylasesIBA
01/2017 - 10/2014
1vafidemstatIBA
07/2022
1Pargyline (Pargyline Hydrochloride)FDA Link
12/2021
1Phenelzine (Nardil)FDA Link
12/2021
1Flavin-Adenine Dinucleotide (FAD)IBA
01/2017
1Monoamine Oxidase (MAO)IBA
02/2016
1Histones (Histone)IBA
03/2015

Therapy/Procedure

3Oral Administration
07/2022 - 02/2016
1Therapeutics
01/2017